Kinetochore assembly throughout the cell cycle
نویسندگان
چکیده
منابع مشابه
Nucleosome architecture throughout the cell cycle
Nucleosomes provide additional regulatory mechanisms to transcription and DNA replication by mediating the access of proteins to DNA. During the cell cycle chromatin undergoes several conformational changes, however the functional significance of these changes to cellular processes are largely unexplored. Here, we present the first comprehensive genome-wide study of nucleosome plasticity at sin...
متن کاملDNA Damage Response and Spindle Assembly Checkpoint Function throughout the Cell Cycle to Ensure Genomic Integrity
Errors in replication or segregation lead to DNA damage, mutations, and aneuploidies. Consequently, cells monitor these events and delay progression through the cell cycle so repair precedes division. The DNA damage response (DDR), which monitors DNA integrity, and the spindle assembly checkpoint (SAC), which responds to defects in spindle attachment/tension during metaphase of mitosis and meio...
متن کاملIMMUNOSUPPRESSION IN HUMAN UTERINE TISSUES THROUGHOUT THE REPRODUCTIVE CYCLE
The purpose of this study was to investigate and compare whether the explant supernatants prepared from endometrial tissues during the proliferative phase, secretory phase and early pregnancy differ in immunosuppressive activity. Specimens of nonpregnant endometrium from hysterectomies and normal first trimester decidua following elective aspiration termination of pregnancy were obtained. ...
متن کاملChromatin Assembly: The Kinetochore Connection
An unexpected new role for the chromatin assembly factor CAF-1 and the histone-regulating Hir proteins has been discovered in budding yeast. Both protein complexes are required together for building functional kinetochores.
متن کاملDynamics of CENP-N kinetochore binding during the cell cycle.
Accurate chromosome segregation requires the assembly of kinetochores, multiprotein complexes that assemble on the centromere of each sister chromatid. A key step in this process involves binding of the constitutive centromere-associated network (CCAN) to CENP-A, the histone H3 variant that constitutes centromeric nucleosomes. This network is proposed to operate as a persistent structural scaff...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Seminars in Cell & Developmental Biology
سال: 2021
ISSN: 1084-9521
DOI: 10.1016/j.semcdb.2021.03.008